There are some non-responders to creatine, approximately 20%-30% of the population. Creatine has shown to increase muscle size and strength in athletes. Creatine has also demonstrated that it lowers myostatin and increases intramuscular IGF-1. This is done by cell volumisation (water retention) and cell energy enhancement (cellular ATP resynthesis). There are new forms of creatine coming out everyday, but creatine monohydrate is the best. Other versions of creatine have not been clinically tested and those that have been, like creatine ethyl ester (CEE) have been less effective than creatine monohydrate.